ectosome

research

Research Field

Developed technology to improve the ability to target stem cells

Advancements in Stem Cell Technology Targeting Undetermined Biomarkers: A New Horizon in Biopharmaceuticals:

In the cutting-edge world of biopharmaceuticals, there emerges a transformative approach for addressing elusive diseases, including those associated with unidentified biomarkers in tumors. Harnessing innovative methodologies, we are pioneering the delivery of potent anticancer drugs to previously inaccessible tumor sites, such as those exhibiting unknown biomarkers, as well as certain types of arthritis. Our research center, specializing in pharmaceutical market-targeted research, boasts the requisite technological infrastructure to augment the homing capacity of stem cells. Additionally, we have fine-tuned a platform technology dedicated to the nano-scale delivery of drugs.
Of particular interest is our endeavor to enhance the homing efficiency of stem cells to challenging tumor sites, including brain and pancreatic cancers. Integral to this mission is our exploration of multi-target strategies, zeroing in on intricate tumor-specific genes. This is achieved through the deployment of stem cells, which feature an orientation towards self-assembled ligand representation. Stay with us as we navigate this promising frontier, potentially heralding a new era in targeted cancer therapies and beyond.

We are exploring technologies to improve homing capabilities for challenging tumors such as brain and pancreatic cancer. We are investigating the role of complex tumor-specific genes in stem cells and cultivating innovative technologies. Through our advancements, we have demonstrated that stem cells with enhanced capabilities exhibit significantly improved tumor targeting in the field compared to their normal counterparts.
Advanced Materials, 2023 (Cover)

Ectosome

Ectosomes: Advanced Extracellular Vesicles Defined

Ectosomes represent a distinct class of extracellular vesicles primarily constituted by cellular membrane components. In stark contrast to exosomes, which originate from the intracellular milieu, ectosomes are generated through a deliberate disruption of the extracellular matrix, leading to the liberation of vesicles formed from the cellular membrane. These vesicles encapsulate a repertoire of molecules reflective of their parent cell membrane's composition.
From an industrial perspective, one of the pivotal benefits of ectosomes lies in their potential for cost-efficient, large-scale production.
At the forefront of this innovative field is the Ectosome Research Center. Through their proprietary technology, they have engineered ectosomes with unparalleled targeting specificity, setting new benchmarks in the realm of vesicle-based research and applications.

ECTO-PLGA®

Ecto-PLGA® is a polymeric nanodrug delivery system that utilizes ectosomes with targeting capabilities. Our patented technology allows the nanodrug to target an array of cancers and arthritis while immensely enhancing stability and encapsulation efficiency.

We extracted ectosomes from enriched, tumor-targeted stem cells and created PLGA-based nanovesicles to analyze the nanovesicles' chemical and physical features (such as size, charge, and morphology) and protein expression. We also conducted protein analysis after ecto-PLGA synthesis to confirm effective synthesis of tumor-targeting proteins. Overall, our results demonstrate successful synthesis of tumor-targeting proteins after ecto-PLGA synthesis.

Pancreatic Tumor-Targeting Stemsome Therapeutics

Advanced Materials 35(30): 2300934 (2023)

Ecto-liposomes are lipid nanocarriers based on Ectosome® and have targeting capabilities.
These nanomedicines effectively target various cancers and arthritis while significantly improving stability and encapsulation efficiency. Several studies using ecto-liposomes are currently in progress.

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